Utilization of Modafinil in Oregon Fee-For-Service Patients
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چکیده
Modafinil (Provigil) is a medication used to promote wakefulness. Originally marketed in 1998, modafinil, a Schedule C-IV drug, was approved by the Food and Drug Administration (FDA) for the treatment of excessive sleepiness (ES) associated with narcolepsy. In 2003, the FDA approved modafinil for the treatment of ES associated with obstructive sleep apnea-hypopnea syndrome (only as an adjunct to standard treatment) and shift work sleep disorder. With the addition of the later two indications, the potential treatment population increased from 135,000 Americans with narcolepsy to 12 million American with sleep apnea and approximate 4 million night shift workers with shift work sleep disorder.1 Recently, a number of case reports, open label studies, and a small number of randomized trials have been published that evaluate the use of modafinil for off-label indications. A brief drug utilization review and literature evaluation follow.
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